Thank you for visiting the Glucosamine Research
Center. This page contains links to current research on glucosamine,
usage information, clinical abstracts and the glucosamine product guide.
The GAIT/GUIDE Study
Description of the clinical study on glucosamine and chondroitin.
Research into the leading commercial products available today.
as Therapeutic Agents in Osteoarthritis
This study collected 13 studies and reviewed them to evaluate the effect of glucosamine on arthritis. Glucosamine was found to be much more effective
than a placebo and at least equivalent, if not superior to, anti-inflammatory drugs and steroids. Glucosamine does not the the side effects that drugs have on the body,
such as the digestive distress, kidney problems and heart conditions. Different products
vary in how much glucosamine they contain but the average amount
recommended is 1500 mg glucosamine a day. The expected cost should be
no more thatn $35 a month.
HCL and Sulfate for the Management of Arthritis
This clinical abstract, published in 1980, suggests that glucosamine
should be considered the basic therapy of choice for primary (develops
with age) or secondary (injury caused) arthritis.
of Glucosamine in Man
Glucosamine was found to be effectively able to diffuse into the
body via oral, such as liquid form, IV (needles into
veins), intramuscular (shots into the muscle). All forms allowed
the glucosamine to be dispersed and absorbed into the body effectively
and thus all three methods are effective routes of administration
HCL and Sulfate Use and Delay of Progression of Knee Osteoarthritis
Glucosamine was again tested for a period of three years against
placebo in a placebo controlled double-blind study, and the results
were astoundingly in favor of Glucosamine.
HCL and Sulfate Significantly Reduced Cartilage Destruction
Glucosamine was shown to be a structure (cartilage) regrowing drug.
In rabbits, the lesions that simulated osteoarthritis were much
smaller in the glucosamine group and much larger in the group that
received nothing (the control group).
Evaluation of Intra-Articular Glucosamine in Gonarthrosis (Knee
A double blind clinical study that evaluated the effects of injected glucosamine verses placebo. Glucosamine reduced pain to a significantly
greater degree than did placebo. The resulting joint flexibility
was much higher with glucosamine therapy. Note: Glucosamine does
*NOT* need to be injected to be effective. The liquid form will
provide quick and effective absorption without daily needle sticks
and the possibility of infections.
Management of Spinal Osteoarthritis with Glucosamine Sulfate
Given the detrimental effects of NSAIDs on joints and other organs,
their use should be discouraged and their classification as a first
choice conservative treatment should be abolished. A more appropriate
treatment for arthritis would involve trying to keep the joints
mobile through exercise and diet, and using glucosamine HCL and sulfate
to aid in the pain reduction and regeneration of destroyed joints.
Compared to Ibuprofen in Osteoarthritis of the Knee
In clinical trials, glucosamine was more effective than placebo
in controlling the symptoms of osteoarthritis. It was also found
to be more effective than Ibuprofen. In addition, a whopping 35%
of Ibuprofen users reported adverse events (generally stomach related)
with their treatment, versus only 6% of the Glucosamine group.
Activity of Oral Glucosamine in Osteoarthrosis
Patients report of pain, stiffness, mobility, tenderness
and swelling of the joint were measured during the trial. The patients
who received the glucosamine experienced twice as much (or more)
pain reduction and this occurred twice as fast (or faster).
In Osteoarthritis - A Systematic Review
This was a study that reviewed other studies that have taken place
on glucosamine, Ibuprofen (an NSAID) and placebo. In every study,
glucosamine was shown to be more effective than placebo
and at least as effective (if not more so) than Ibuprofen, which
carries risks when it is used for long periods of time. Overall,
glucosamine has been shown to be an effective therapeutic nutraceutical
for certain kinds and locations of arthritis with almost no side
and Safety of Glucosamine Versus Ibuprofen in Patients with
Both glucosamine and ibuprofen significantly reduced the symptoms
of osteoarthritis, with glucosamine being more effective.
After 2 weeks of drug discontinuation there was a remnant therapeutic
effect in both groups, with the trend to be more pronounced in the
glucosamine group. Glucosamine was significantly better tolerated
than ibuprofen, as shown by the adverse drug reactions.
Properties of Glucosamine
The therapeutic effects of glucosamine with regard to the anti-inflammatory
activities seems comparable or superior to that of the known non-steroidal
anti-inflammatories (NSAIDS) such as ibuprofen, naproxen or aspirin.
Compared to the NSAIDS, glucosamine side effects were virtually absent. Glucosamine also lacks
the eroditive effects of long term NSAIDS use.
For more Clinical Studies, continue on to the Glucosamine
Research Page 2
Be sure to visit the Glucosamine
Product Guide for a review of commercially available glucosamine