Nutraceuticals as Therapeutic Agents in
Osteoarthritis. The Role of Glucosamine, Chondroitin Sulfate, and
review of the literature related to studies that
examine the effectiveness of glucosamine and chondroitin
in the treatment of osteoarthritis. A total of 13
studies were investigated in this meta analysis.
Some design flaws were identified in many of the
studies, however, all the studies examined showed
a large effect for the use of glucosamine and chondroitin
in the treatment of osteoarthritis. Glucosamine
sulfate was evaluated and found to be more effective
than a placebo in all trials examined and equal
to or better than ibuprofen in other trials. Chondroitin
sulfate was also examined for its effectiveness
and found in all trials to be more effective at
alleviating pain than the placebo. Although different
products vary with respect to how much glucosamine
and chondroitin is in the product, the preferred
amount appears to be 1500 mg of glucosamine and
1200 mg of chondroitin. The expected amount of cost
should be from $30-$45 a month for the product.
While extensive reviews of the the side effects
of the products are limited, most studies have participants
who tolerate the glucosamine and chondroitin well
and report few side effects.
Deal CL. Moskowitz RW.
Division of Rheumatology, Case Western Reserve University School
of Medicine, University Hospitals, Cleveland, Ohio, USA.
Country of Publication:
Rheumatic Diseases Clinics of North America. 25(2):379-95, 1999
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Be sure to visit the Glucosamine Product Guide for a review of commercially available glucosamine products broken down by 9 different categories such as price per month, quality and type. Learn what the best products out there are and what criteria was used to ranked each.